1.7 C
New York
Tuesday, February 17, 2026
Home Blog Page 1026

New prostate cancer treatment could be on the horizon, say UK researchers: ‘Tremendously exciting’

0

Prostate cancer patients could have a new treatment on the horizon.

A new study published in the journal Nature has found that for some patients with treatment-resistant prostate cancer, a new process can “block” the messages that cancer uses to “hijack” white blood cells.

In early clinical trials, researchers from The Institute of Cancer Research in the U.K. found that this process made advanced prostate cancers more treatable, “shrinking tumors or halting their growth,” according to a press release from the university.

PROSTATE CANCER SYMPTOMS, WARNING SIGNS AND TREATMENT

The researchers targeted “feeder” myeloid white blood cells, which are typically pulled into cancer tumors to advance the disease. This was the first human trial to show that this approach can slow the growth of cancer tumors and make them more responsive to treatment.

In the study, patients with advanced disease received two medications: AZD5069, an experimental drug that blocks cancer cells from “hijacking” myeloid cells to feed tumors, and enzalutamide, a hormone therapy commonly used to treat prostate cancer.  

A new study published in the journal Nature has found that for some patients with treatment-resistant prostate cancer, a new process can “block” the messages that cancer uses to “hijack” white blood cells. (iStock)

Among a small group of patients with advanced prostate cancer, 24% of them responded to the treatment, meaning their tumors shrunk by more than 30%, according to the press release.

FLORIDA MEDICAL TECH COMPANY LAUNCHES NOVEL AI TEST FOR PROSTATE CANCER THERAPY

They also saw “dramatic decreases” in prostate-specific antigens (PSA), a marker that is often higher for cancer patients.

Patients who received the treatment also had lower levels of myeloid cells in their tumors.

In addition to The Institute of Cancer Research, other participating universities included The Royal Marsden NHS Foundation Trust in London and The Institute of Oncology Research (IOR) in Switzerland, which have been working on the research for more than a decade.

Man at doctor

Prostate cancer is the leading cancer diagnosis among men, and about one in every 41 men will die of the disease.  (iStock)

“This research proves for the first time that targeting myeloid cells rather than the cancer cells themselves can shrink tumors and benefit patients,” said study leader Johann De Bono, professor in experimental cancer medicine at The Institute of Cancer Research, London, in the press release. 

“This is tremendously exciting, and it suggests we have an entirely new way to treat prostate cancer on the horizon.”

This treatment could eventually be extended beyond just prostate cancer, De Bono added.

FISHING AND ITS HEALTH BENEFITS: THE MORE MEN GO FISHING, THE BETTER THEIR MENTAL HEALTH, STUDY FINDS

“This strategy may have broader benefits to sufferers from other cancer types,” he told Fox News Digital.

Study limitations

The key limitation of the research was the small sample size, the researcher noted.

“It is a small trial that needs confirmation in future studies,” De Bono told Fox News Digital, emphasizing the need to “pursue further trials with better drugs to maximize patient benefit as soon as possible.”

Prostate scan

Among a small group of patients with advanced prostate cancer, 24% of them responded to the treatment, meaning their tumors shrunk by more than 30%. (iStock)

Dr. William M. Rafelson, director of genitourinary oncology at Atlantic Health System in New Jersey, noted that effective drugs are “desperately needed” for this disease — especially for metastatic castration resistant prostate cancer, which occurs when the cancer stops responding to hormone treatment and spreads to other parts of the body.

Most patients with metastatic castration prostate cancer often succumb to their illness within two to three years, noted Rafelson, who was not involved in the study.

MEN’S HEART DISEASE RISK DOUBLES WITH THESE TYPES OF JOB STRAIN, SAYS NEW STUDY

“This study is exciting in that it is looking closely at the role of specific white blood cells in our immune system, called neutrophils,” he told Fox News Digital. 

“While these cells are essential first responders to bacterial, fungal and other infections, they can also run rampant, leading to harmful levels of inflammation that can fuel cancer growth and hamper the ability of other immune cells to kill the cancer.”

Patient talking to doc

Most patients with metastatic castration prostate cancer often succumb to their illness within two to three years, noted an oncologist. (iStock)

Rafelson noted that this study is the first of its kind in prostate cancer, showing that blocking a part of the patient’s immune system can reverse the resistance to hormone therapy in late-stage prostate cancer.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

“Ongoing questions are whether this therapy will continue to prove to be safe, if the rate of response will be the same or higher in a larger group of patients, and how we can better identify responders before we treat them,” he added.

CLICK HERE TO GET THE FOX NEWS APP

Prostate cancer is the leading cancer diagnosis among men, and about one in every 41 men will die of the disease, according to the American Cancer Society (ACS).

For more Health articles, visit www.foxnews.com/health.

NFL owner goes viral for unique dance moves after Aces claim back-to-back WNBA championships

0

The Las Vegas Aces became the first WNBA team in more than two decades to win back-to-back championships with a narrow victory in Game 4 of the WNBA finals on Wednesday night, and owner Mark Davis could hardly contain himself. 

Davis, owner of the Aces and the Las Vegas Raiders, saw his team defeat the New York Liberty 70-69 in a thrilling comeback victory to become repeat champions. 

Las Vegas Aces owner Mark Davis celebrates with the team after defeating the New York Liberty during Game Four of the 2023 WNBA Finals at Barclays Center on October 18, 2023, in New York City. The Aces defeated the Liberty 70-69. (Sarah Stier/Getty Images)

The last team to do it was the Los Angeles Sparks in 2002. Only one other team has ever won consecutive championships – the Houston Comets won four consecutive titles from 1997 to 2000. 

LIBERTY GUARD SABRINA IONESCU THROWS UP COURTSIDE DURING WNBA FINALS LOSS

“You get three great women No. 1,” Davis said during the trophy presentation as to what his recipe for success was.  

“You got Nikki Fargas as president, you got Natalie Williams as general manager and you’ve got Becky Hammon – the greatest coach in the world. You get 12 wild women that also know how to play some basketball, and you’ve got a team. And Las Vegas, we are still world champions!” 

Mark Davis celebrates the Aces championship

A’ja Wilson, #22 of the Las Vegas Aces, celebrates with her team after defeating the New York Liberty during Game Four of the 2023 WNBA Finals at Barclays Center on October 18, 2023, in New York City. The Aces defeated the Liberty 70-69.  (Sarah Stier/Getty Images)

The Aces, and Davis, wasted no time in celebrating their victory, and soon the longtime NFL owner found himself at the center of a dance circle. 

CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM

Davis’ moves may have not been smooth, but WNBA fans could see a similar sight next season. 

Talks of a possible three-peat for the Aces have already made their rounds in the media. 

WNBA Finals MVP A’ja Wilson, Kelsey Plum, Jackie Young and Chelsea Gray – all in their prime – are posed to return next season, and at the helm will be Hammon.

Mark Davis celebrates the Aces championship

Las Vegas Aces owner Mark Davis celebrates with the team after defeating the New York Liberty during Game Four of the 2023 WNBA Finals at Barclays Center on October 18, 2023, in New York City. The Aces defeated the Liberty 70-69.  (Sarah Stier/Getty Images)

CLICK HERE TO GET THE FOX NEWS APP

“This one’s sweeter, it just is,” Hammon said after the game. “It’s harder to do.” 

The Associated Press contributed to this report. 

 

Why the 2024 Bitcoin halving may play out differently than in the past

0



f1ff6c73 1d65 4f4d bfb9 7217a68195c9

The impact of the Bitcoin halving on crypto prices is often overestimated and the next halving, set for April 2024, may play out differently than previous ones, according to a leading analyst.

The halving event, which every four years, cuts in half the rate by which new Bitcoins are created, and is generally considered one of the main catalysts driving Bitcoin’s biggest upside moves.

Despite the bullish narrative surrounding the halving, however, the event by itself does not guarantee the appreciation of Bitcoin.

If the reduced supply of new Bitcoin is not accompanied by significant demand, prices are unlikely to surge.

Also, the halving is an entirely predictable event: that means all market participants know in advance when it will occur and therefore its current price may already be reflective of the halving’s impact before it happens.

“Things that we most anticipate generally don’t happen,” said Bloomberg analyst Mike McGlone, commenting on the much anticipated event.

“And that’s what I’m concerned about. It’s complete consensus,” he continued.

Also, each time the halving occurs, its impact on the new Bitcoin supply decreases; over time, its impact will eventually become irrelevant. Changes in demand, rather than supply, are therefore becoming the dominant factor influencing the price of Bitcoin.

So, how will the next Bitcoin halving impact the crypto market? And, if not the halving, what is the catalysts behind Bitcoin’s cyclical upside moves?  To find out, check out our latest Cointelegraph Report on our YouTube channel and don’t forget to subscribe!



Source link

12 practical tips for effectively working with regulators

0



979d3d0e 2881 4893 a96f 7d2614ddf283

The world is interested in crypto. In the United States and European Union, individual investors have shown they are intrigued by its possibilities, while emerging economies are leveraging it to expand access to financial services. This, of course, is attracting the focus of legislators who want to both tap into crypto’s potential and ensure investors and consumers are well-protected. But with crypto’s international footprint, new and dynamic technologies, and built-in anonymity, it’s a challenge to protect users’ privacy and police unlawful activity.

It’s likely impossible for regulators to walk the fine line between encouraging innovation and protecting consumers without developing adaptable, deliberate and internationally coordinated regulatory measures — and for that, they need the help of crypto leaders. It’s an effort well worth those leaders’ time if they wish to enhance industry credibility, attract new users and avoid complex (even punitive) legislation that could hinder innovation. Below, 12 members of Cointelegraph Innovation Circle offer practical tips for crypto leaders on working individually and as an industry with regulators for the benefit of both sides — and the future. 

Focus on use cases without specific binary regulatory requirements

The involvement of leaders who are tech-savvy and understand how regulatory systems apply is important. Financial systems and technology were very different when regulations were first developed. Consumer protection and market integrity are still the primary objectives, but the means to achieve them have changed. Leaders can add value by working with regulators to focus on use cases without specific binary regulatory requirements. – Tammy Paola, Zerocap

Prioritize transparency and education

Engage proactively with regulators, prioritizing transparency and education. Understand their concerns and position your dialogue as a partnership. Demonstrating a commitment to ethical practices and consumer protection can foster mutual trust and clearer regulatory pathways. – Tomer Warschauer Nuni, Kryptomon

Recognize that regulation can be an ally

Crypto leaders should recognize that regulation can be an ally. Crypto’s “Wild West” nature invites scammers like FTX and Terra, so embracing regulation with thoughtful collaboration helps the ecosystem as a whole, allowing the crypto industry to become more secure and credible while protecting investors. Leaders should encourage transparency and responsible practices, and work with regulators to build trust in the industry. – Ayelet Noff, SlicedBrand

Document everything regulators tell you

Engage with your regulators, but document everything that they have told you, especially promises or implied support. Know everything there is about applicable laws in your country, and try to stay clear of flagrant violations of those laws. Always know when they are trying to pitch a novel argument to the courts, and know how to defend yourself. – Zain Jaffer, Zain Ventures

Help assuage regulators’ concerns

Approach the conversation from the perspective of assuaging regulators’ concerns. Often when seeking to craft legislation, regulators approach the industry and are met with distrust or even hostility. Businesses should focus on educating and informing governments about the priorities of the industry and how they can get there while not risking contagion to other parts of the financial system. – Jason Fernandes, AdLunam Inc.

Listen closely to regulators’ input

In the world of music, crypto is avant-garde jazz, while regulators are more attuned to classical notes. To make harmonious music, listen closely, blend your innovative riffs with their timeless chords, and compose a symphony of progress together. It’s not about overpowering, but about creating a new genre that resonates with all. – Arvin Khamseh, SOLDOUT NFTs

Help shape regulations that benefit both sides

Let’s keep in mind that many regulators are in the process of grasping and understanding the Web3 industry. Hence, every Web3 company should contribute to shaping regulations that benefit both sides. The most effective approach involves showing a readiness to cooperate, tackle concerns and educate regulators, fostering the most favorable outcomes possible. – Sheraz Ahmed, STORM Partners

Consider how similar companies in the industry can work together

Build upon the premise that we will get farther together. Even companies working on the same or similar products should consider how they can work together to achieve goals beyond their individual growth. The industry is still in its infancy, and we will find mainstream adoption and tremendous success together, especially when working with regulators. – Megan Nyvold, BingX

Be cautious, compliant and patient

Regulators aim to make things the best they can for all parties involved, but sometimes that process takes time. This is why it’s always a good idea to be cautious and compliant while also being hyper aware that things may not work out at first. Documenting everything and helping to find solutions is recommended, as this space is a work in progress for everyone — but the end goal is the same. – Ilias Salvatore, Flooz XYZ

Offer direct and clear assistance toward shared goals

As a cousin of trust, transparency should be top of mind for companies seeking to collaborate and build strong foundations with regulators across any jurisdiction. These officials are in place to protect the safety and security of participants in their region. By offering direct and clear assistance toward that goal, crypto leaders can make sure understanding is sustained through mutual respect. – Oleksandr Lutskevych, CEX.IO

Address myths and false information about crypto

My advice for crypto leaders is that they try to deal with the myths and false information that has been revolving around crypto as an ecosystem. Many of these myths can be addressed through accurate data. For example, the drawbacks of proof-of-work are used to malign the image of the entire world of cryptocurrencies. Another example is working against the image of crypto being used to avoid taxation. – Abhishek Singh, Acknoledger

Proactively undergo third-party audits and certifications

Leverage third-party audits and certifications to show compliance and security. Regulators may not be blockchain experts, but they understand audits. Proactively undergoing these evaluations can make a compelling case for your project’s legitimacy, potentially speeding up regulatory approvals and fostering a cooperative relationship with authorities. – Tiago Serôdio, Partisia Blockchain


This article was published through Cointelegraph Innovation Circle, a vetted organization of senior executives and experts in the blockchain technology industry who are building the future through the power of connections, collaboration and thought leadership. Opinions expressed do not necessarily reflect those of Cointelegraph.



Source link

Liberty guard Sabrina Ionescu throws up courtside during WNBA Finals loss

0

New York Liberty guard Sabrina Ionescu was feeling the pressure during Game 4 of the WNBA Finals on Wednesday night. 

After hitting a massive 3-pointer less than halfway through the fourth quarter with the Liberty trailing the Las Vegas Aces, the former Oregon standout hurried over to the sideline and vomited into a trash can. 

Sabrina Ionescu of the Liberty drives against the Las Vegas Aces during Game 4 of the WNBA Finals at Barclays Center on Oct. 18, 2023, in New York City. (Sarah Stier/Getty Images)

At the time, New York was on the brink of losing the championship to the Aces, who had taken a 2-1 lead in the Finals. 

LIBERTY OWNER JOE TSAI GETS LAST LAUGH AFTER ESPN STAR CRITICIZES TEAM’S FAN BASE

The incident didn’t appear to be cause for concern, however. According to ESPN sideline reporter Andraya Carter, Ionescu revealed that she battles through nerves before stepping on court. 

“You talk about nerves in a Finals moment, Sabrina Ionescu who just hit a big 3 and came over to the sideline and lost the contents of her stomach, she told me that she gets nervous before games but she went right back out, wiped off her chin and kept on playing.” 

CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM

New York suffered blowout losses to the Aces in Games 1 and 2, losing 99-82 in the opening game of the championship and 104-76 the next. On the brink of elimination, the Liberty pulled off an 87-73 win on Sunday night to force a Game 4. 

After leading in the first half of Wednesday night’s game, New York allowed the Aces room to climb back. With the game tied at 64, Las Vegas scored six straight points, including the first four by Jackie Young, to go ahead 70-64 with 1:26 left.

Sabrina Ionescu drives toward the net

Sabrina Ionescu of the New York Liberty drives against the Las Vegas Aces at Barclays Center on Oct. 18, 2023, in New York City. (Sarah Stier/Getty Images)

In a heartbreaking finish for the Liberty, Courtney Vandersloot’s missed 3-pointer handed the Aces a 70-69 victory to become repeat champions. 

CLICK HERE TO GET THE FOX NEWS APP

“It’s tough. It’s tough to win a fourth,” New York head coach Sandy Brondello said after the game. “It would’ve been nice to go and play Game 5 and then lay it all out on the table.”

Sabrina Ionescu reacts during the WNBA Finals

Sabrina Ionescu of the New York Liberty reacts after a play during the WNBA Finals game against the Las Vegas Aces at Barclays Center on Oct. 18, 2023, in New York City. (Sarah Stier/Getty Images)

“You know, we fought but it wasn’t our best game today. It’ll be a hard one to learn from, but in the end I’m proud of this group, of what we accomplished, and how we’ve come together as a totally new group and trying to build the chemistry and the togetherness and they committed to what we wanted to do. We’ve got to take it as a learning experience now and as we move forward remember how it feels and use it as motivation.”

The Associated Press contributed to this report.

Seahawks’ DK Metcalf ‘not going to change the way I play’ despite penalties

0

Seattle Seahawks wide receiver DK Metcalf received his fifth penalty of the season on Sunday when he was flagged for an unnecessary roughness penalty against the Cincinnati Bengals. 

Metcalf shoved Bengals defensive back Cam Taylor-Britt down the field, drawing the flag. 

Cincinnati Bengals’ Cam Taylor-Britt, #29, breaks up a pass intended for Seattle Seahawks DK Metcalf, #14, during the first half of an NFL football game on Sunday, Oct. 15, 2023, in Cincinnati. (AP Photo/Jeff Dean)

On Wednesday, Seahawks head coach Pete Carroll was asked about Metcalf’s propensity for being flagged, with the Super Bowl-winning coach saying his wideout was aware of the issue.

CHIEFS’ PATRICK MAHOMES WANTS TO OWN NFL TEAM ONCE HE’S DONE PLAYING 

“We put all the penalties on the board in Monday’s meetings and the guys who had the most were on the top, and he was up there with another guy,” Carroll said, according to ESPN. “We all have to acknowledge it and recognize what our issues are, whatever they are. It happens to be in this case he’s getting called.

“He knows. He’s got to clean it up. We have to make sure we’re aware of how they’re calling stuff. He’s a very aggressive player, very physical and it stands out and he draws attention because of that. So we’ve got to be cleaner. He knows it and he’s got to get it done.”

Metcalf took a different approach when asked about Carroll’s “penalty board,” saying he would not be changing who he is on the field. 

CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM

DK Metcalf plays against Cincinnati

Seattle Seahawks wide receiver DK Metcalf, #14, in action during the game against the Seattle Seahawks and the Cincinnati Bengals on Oct. 15, 2023, at Paycor Stadium in Cincinnati. (Photo by Ian Johnson/Icon Sportswire via Getty Images)

“It was just a board to me. I’m not going to change the way I play,” Metcalf said. “If you look at the penalties, there’s a taunting, unnecessary roughness, facemask, holding, and I think there was one more in there. So, I’m doing pretty good if I look at it and judge myself how I play.”

“I’m not going to change who I am as a player or a person,” Metcalf continued. 

Sunday’s penalty against the Bengals was the fourth 15-yard penalty for Metcalf, with one resulting in offsetting penalties, according to The Associated Press. 

“Have you had a bad day at work sometimes?” Metcalf responded when a reporter asked if any of the penalties came about as being “caught up in the moment.” 

CLICK HERE TO GET THE FOX NEWS APP

DK Metcalf and Pete Carroll speak with officials

Seattle Seahawks wide receiver DK Metcalf, #14, and head coach Pete Carroll talk to side judge Jim Quirk, #5, during the game against the Seattle Seahawks and the Cincinnati Bengals on Oct. 15, 2023, at Paycor Stadium in Cincinnati. (Ian Johnson/Icon Sportswire via Getty Images)

“That’s all I nail it down to. Nobody’s perfect. I’m my own person. I’m a competitive person. So, I’m not going to shy away because he put a penalty board on the screen. I’m just going to continue to be me.”

Despite the penalties, Metcalf is leading Seattle in receiving yards this year, hauling in 22 catches for 337 yards and two touchdowns. 

The Seahawks are 3-2 as they prepare for the Arizona Cardinals in Week 7. 

What is the Pareto 80/20 rule, and how does it apply to cryptocurrencies?

0



777717e0dca0eb19a2cebc237d97d1cd

The Pareto principle, explained

The Pareto principle emphasizes how crucial it is to identify key players, major cryptocurrency or influential projects.

According to the Pareto principle, commonly referred to as the 80/20 rule, roughly 80% of outcomes result from 20% of causes. Vilfredo Pareto, an economist from Italy, observed that 20% of the population in Italy controlled 80% of the country’s land at the beginning of the 20th century. 

Since then, this principle has been employed in many different sectors over the years and is frequently invoked to highlight the uneven distribution of results. But what does the 80/20 rule mean for blockchain technology?

In the context of cryptocurrencies, the Pareto principle can be observed in several ways:

Blockchain network security

A small percentage of nodes — usually around 20% — carry the bulk of the computational workload for network security, safeguarding the integrity and safety of the whole blockchain network. These nodes, which are frequently run by significant entities, contribute disproportionately to preserving the stability of the network.

Wealth distribution

A small percentage of wallet addresses possess the vast majority of the coins for several cryptocurrencies. This small group of investors, often referred to as “whales,” can significantly influence the market due to their substantial holdings. The 80/20 rule is in line with this wealth concentration.

Project success

The vast majority of investor interest and investment in the realm of initial coin offerings (ICOs) and token launches goes to a relatively small number of projects. The 80/20 rule of success is a result of investors concentrating their capital on businesses with strong teams, original concepts and promising technologies.

Smart contracts usage

The majority of cutting-edge and widely adopted applications are created by a small group of developers and users on blockchain platforms like Ethereum that support smart contracts. This small cohort of people and businesses makes a substantial contribution to the creation and application of smart contracts, influencing the development of blockchain technology as a whole. 

Ethical concerns related to the concentration of wealth in the crypto space

Due to its propensity to encourage market manipulation, prolong inequality, restrict financial inclusion, and amplify environmental problems, the concentration of wealth in the cryptocurrency field poses ethical questions. 

Significant ethical questions are raised by the wealth concentration in the crypto industry, which reflects deeper socioeconomic problems. The unequal distribution of resources is one of the primary worries. The power imbalance that results from wealth concentration by whales undermines the decentralized spirit that cryptocurrencies want to promote while also perpetuating existing injustices.

Additionally, market manipulation may result from wealth concentration. Due to their huge holdings, whales have the power to affect market prices, creating artificial volatility that hurts smaller investors. Moreover, the widespread concerns about insider trading, pump-and-dump schemes and other types of market manipulation erode confidence in the entire cryptocurrency ecosystem.

The digital divide is widened by the concentration of wealth in cryptocurrencies. Access to financial services, decentralized applications (DApps) and investment opportunities becomes increasingly important as blockchain technology develops. The democratizing potential of cryptocurrencies is constrained when wealth is concentrated in the hands of a small number of people, impeding financial inclusion and social advancement.

Another ethical issue is the effect on the environment. The mining of cryptocurrencies, especially in proof-of-work (PoW) systems, needs a lot of processing power, which uses a lot of energy. When a small number of companies dominate most mining operations, the environmental cost increases, creating moral concerns about resource sustainability and efficient use of resources.

These ethical concerns may be addressed using a multifaceted approach. Some of these problems can be mitigated by promoting wider acceptance of cryptocurrencies, increasing transaction transparency, and other measures. Additionally, developing a more inclusive crypto environment in line with ethical ideals can be achieved by supporting and promoting decentralized finance (DeFi) initiatives that strive to build more egalitarian financial systems.

Economic and financial institutions known as egalitarian financial systems work to close or eliminate wealth, income and opportunity gaps by promoting equality and fairness among people or groups. In such systems, regardless of socioeconomic status, ethnicity, gender or any other criteria, every participant is treated equally in terms of access to financial resources, economic possibilities and fundamental services.

The impact of governance structures on cryptocurrencies: A Pareto perspective

The 80/20 rule, which states that decisions are frequently significantly influenced by a small fraction of participants, can be used to examine the Pareto effect of governance structures on cryptocurrencies. 

The Pareto principle affects cryptocurrency governance structures in the following ways:

Decision-making power concentration: 20% influence, 80% decisions

A considerable amount of the overall supply (about 20%) is frequently controlled by a very small number of major investors, early adopters or powerful institutions in many cryptocurrency networks. These organizations have a disproportionate amount of influence (about 80%) over governance choices as a result of their significant holdings. They have the power to influence decisions about proposals, votes and protocol updates in ways that benefit them.

Voting and proposal systems: 20% active participants, 80% votes

Only about 20% of tokenholders (on average) actively participate in governance mechanisms like voting and proposal systems. But typically, these 20% of participants cast around 80% of the total votes. As a result, this active minority has a significant impact on decisions.

Impact on upgrades and development: 20% funding, 80% development

When cryptocurrencies use funding methods such as treasuries or development grants, only a few businesses or projects (about 20%) may receive the majority (nearly 80%) of the funding. Because of this, these well-funded projects have a bigger influence on the advancement and development of cryptocurrency.

Governance token distribution: 20% holders, 80% influence

A small percentage of tokenholders (about 20%) frequently control the majority of the tokens (around 80%) in systems that use governance tokens. As a result, these holders have a significant influence over decisions and proposals, which has an effect on the cryptocurrency’s general course.

Cryptocurrency investment strategies based on the Pareto 80/20 rule

Investors can better control their risk and increase their potential for sustained gain by adhering to the 80/20 rule as they traverse the complex crypto ecosystem.

Leveraging the Pareto principle may help direct a strategic and focused approach for crypto investors. Investors can focus their resources on the top 20% of reputable and influential cryptocurrencies rather than dispersing their investments across a large number of digital assets.

This strategic focus enables a greater comprehension of the key market participants, empowering investors to make wise choices based on in-depth investigation and analysis. Investors can take advantage of these established assets’ stability and market dominance by devoting the majority of their investment portfolio to these significant cryptocurrencies.

Furthermore, the 80/20 rule can extend to the investment timeline. Investors might consider adopting a long-term perspective and allocating 80% of their capital to established cryptocurrencies designed for long-term ownership. 

This strategy is in line with the idea that the key to steady, long-term growth is to concentrate on the most valuable assets. The remaining 20% of the portfolio can be used for short- or medium-term transactions, allowing investors to take advantage of market volatility for more rapid gains.

How to mitigate the negative impact of the 80/20 rule on cryptocurrencies

To reduce the Pareto principle’s unfavorable effects on the crypto industry, fairness, accessibility and inclusivity must be actively promoted.

Projects should concentrate on putting equal-opportunity policies into action to combat the concentration of wealth and power. One strategy is to support decentralized access to financial services, removing geographical and socioeconomic restrictions.

Additionally, projects should think about setting up fair launches and airdrops, distributing tokens widely across the community and preventing early adopters from receiving an unfair advantage from token sales or ICOs.

Moreover, developing educational tools and programs that are open to everyone, regardless of their history or financial standing, can equip people with the knowledge they need to properly engage in the cryptocurrency space.

Progressive decentralization is a novel strategy for reducing the Pareto principle’s negative effects on the crypto industry. For effective decision-making, this model calls for an initial phase of centralization, followed by a gradual transition toward decentralization.

Using this approach, users are empowered by the transparent implementation of processes like decentralized governance and community voting, which guarantee an even distribution of power and promote a more equitable crypto economy.



Source link

Potential speaker candidates emerge from shadows as Jordan’s bid falters

0

Potential challengers are waiting in the wings for Judiciary Chairman Jim Jordan, R-Ohio, to step away from the race for House speaker after he failed to clinch a majority of support in back-to-back House-wide votes.

Rep. Jack Bergman, R-Mich., a retired Marine Corps general, is “prepared” to step into the race if Jordan falters, his spokesman told Fox News Digital. Bergman had supported Jordan throughout his run for speaker.

“Following the second round of voting, the General was approached by colleagues and has had conversations about a possible Speaker run — it’s becoming clear Rep. Jordan’s path is narrowing by the hour,” the spokesman said.

“We cannot go another day without a Speaker. He simply doesn’t have the votes — we need to have a frank discussion as a conference about a path forward. If as a conference we see he can’t get the necessary votes to become Speaker, General Bergman is prepared to step up.”

EFFORT TO EMPOWER INTERIM SPEAKER MCHENRY GAINS STEAM AS JORDAN MOMENTUM STALLS

Rep. Jack Bergman, right, a retired Marine Corps general, is considering jumping into the race for speaker if Judiciary Chairman Jim Jordan, left, proves unable to clinch the gavel

Bergman is seeking to cast himself as a stable force to lead the House until the new term begins in 2025.

“The General isn’t seeking to climb the ladder, only steady it in a time of chaos — and would only seek to be Speaker for the remainder of the 118th Congress,” his spokesman said. “Rep. Bergman served our Nation for 40 years in the United States Marine Corps — retiring as a Lt. General. He knows how to put others first to accomplish the task at hand.”

Meanwhile, a source familiar with discussions told Fox News Digital that Budget Committee Chairman Jodey Arrington’s name “keeps popping up as an alternative in conversations with holdouts unhappy with Jordan.”

JORDAN LOSES HIS SECOND SPEAKER VOTE AS NEARLY TWO DOZEN REPUBLICANS OPPOSE HIM

Arrington, R-Texas, would be an attractive candidate for establishment Republicans due to his experiences working under former President George W. Bush’s administration, the source said, while his recently produced budget framework to slash spending could be appealing to hardline conservatives.

A different source familiar with Arrington’s plans said, “We really are working to get Jordan to 217, and we are standing by our Conference nominee. Getting this done and getting back to doing the People’s work is what we’re laser-focused on right now.”

Arrington Jodey

Rep. Jodey Arrington leaves the House Republican Conference meeting at the Capitol Hill Club on Wednesday, May 16, 2018. (Getty Images)

The first source also mentioned Republican Study Committee Chair Kevin Hern, R-Okla., as “another alternative waiting in the wings.” Hern had toyed with the idea of running for speaker before stepping back from the race over concerns a three-way competition could fracture the House GOP.

Other reports have also suggested Rep. Mike Johnson, R-La., vice chair of the House GOP conference, as a possible candidate. A third source close to discussions acknowledged hearing “whispers” about Johnson.

HOUSE GOP SELECTS JORDAN AS SPEAKER CANDIDATE, TEEING UP HOUSE-WIDE VOTE

mike johnson speaks

Rep. Mike Johnson speaks during a hearing of the House Judiciary Committee on Capitol Hill on July 14, 2022 in Washington, DC. The committee heard testimony on threats to individual freedoms after the U.S. Supreme Court reversed the Roe v Wade decision on abortions.   (Tasos Katopodis/Getty Images)

A moderate Republican lawmaker even floated Rep. Chip Roy, R-Texas, who has emerged this year as a top liaison between GOP leadership and the hardline-right House Freedom Caucus. 

“Conservatives want Jim Jordan. But Jim Jordan isn’t going to get the job done and doesn’t have our support. Chip Roy would be a different story. He’s principled,” the lawmaker told Fox News Digital.

CLICK HERE TO GET THE FOX NEWS APP

Hern and Johnson’s offices did not immediately respond to a request for comment Thursday morning.

Jordan won 199 votes in his second try at the speaker’s gavel on Wednesday, after winning 200 the previous day. 

His office has indicated that he will go through another vote on Thursday, but it’s likely to be the final bellwether on whether Jordan’s candidacy still has viability.

Ex-NFL player Rashad Jennings suffers brutal ‘Wheel of Fortune’ mishap on simple puzzle

0

Former NFL running back Rashad Jennings is apparently not too familiar with the work of famed Hollywood director Quentin Tarantino. 

Jennings, who played eight years in the NFL before retiring in 2017, was a contestant in Wednesday’s episode of “Celebrity Wheel of Fortune” when he committed the worst blunder one could face on the show – incorrectly guessing a puzzle with just one letter remaining. 

Running back Rashad Jennings of the New York Giants celebrates after scoring a touchdown against the Jaguars at EverBank Field on Nov. 30, 2014, in Jacksonville, Florida. (Alex Menendez/Getty Images)

The former New York Giants player needed the letter “Q” to complete the puzzle “driving to Reno with Quentin Tarantino,” but instead shouted the letter “P.” 

CONTROVERSY ERUPTS AT END OF GIANTS-BILLS GAME AS FANS DEBATE NO-CALL ON DARREN WALLER CATCH ATTEMPT

“No, I’m sorry no,” longtime host Pat Sajak said with disappointment.

Jennings, 38, was playing for his organization The Rashad Jennings Foundation.

“We focus on health, leadership, mentorship and reading,” he said in a video posted on social media. 

CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM

Rashad Jennings avoids a tackle

Haloti Ngata of the Detroit Lions attempts to tackle Rashad Jennings of the New York Giants at MetLife Stadium on Dec. 18, 2016, in East Rutherford, New Jersey. (Jeff Zelevansky/Getty Images)

“Literacy is a big deal to me. I grew up with a 0.6 GPA at one point in time, overweight chubby kid with glasses, asthma and I’ve overcome that to become a New York Times bestseller and I have a reading challenge in about over 500 schools right now. We’ve had over 500,000 books read in the last 10 years, something I’m very proud of and we’re going to continue to do.” 

But Jennings made light of the mishap while teasing his appearance on Instagram. 

“Catch me on Wheel Of Fortune tomorrow night! You will definitely get a laugh,” he wrote in a post. 

CLICK HERE TO GET THE FOX NEWS APP

Rashad Jennings rushes the ball

Rashad Jennings of the New York Giants runs the ball against the Chicago Bears at MetLife Stadium on Nov. 20, 2016. (Jeff Zelevansky/Getty Images)

Jennings spent eight years in the NFL. He was drafted by the Jacksonville Jaguars in the seventh round of the 2009 NFL Draft. After a brief stint with the Raiders, Jennings was signed by the Giants in 2014 and he immediately took over as a starter. 

He retired in 2017 and finished his career with 3,772 rushing yards and 23 touchdowns.

Diving into cross-chain DeFi lending

0



6d997f85 27f5 4136 9f55 7b4ac7944ec0

Cointelegraph’s Hashing It Out podcast talked with MultiChainZ chief operating officer Aanchal Thakur to discuss a popular decentralized finance (DeFi) use case: lending. Host Elisha Owusu Akyaw and Thakur explored what makes a cross-chain lending platform different from other platforms and the potential risks it entails. Other highlights include conversations about institutions, DeFi lending, nonfungible token lending, and how projects embrace decentralized autonomous governance. 

Thakur started her cryptocurrency journey by falling for a crypto doubling scam, which she claims taught her an important lesson to take her research of the industry more seriously. She went on to work on multiple projects before moving to MultiChainZ.

Thakur argued there is a strong case for building a cross-chain lending platform. She explained that funds are unavailable for many people globally, and that creating a lending and borrowing platform that cuts across multiple networks opens users up to more sources of liquidity.

The MultiChainZ exec also argued that overreliance on a single network may expose projects to a high level of risk. She explained that one of the proper ways to ensure decentralization is to use multiple networks.

“If a blockchain is not working for even two hours, when Solana was down for a few hours, it impacted so many users. It impacted the trust of those users. So, we realized that it does not make sense to build a product on a particular blockchain.“