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The onset of dementia can come as a shock, but various signs could predict the condition as long as 20 years before symptoms.

A new study published by the RAND Corporation in California identified several major predictors occurring around age 60 that are likely to lead to cognitive impairment and dementia by age 80.

Researchers evaluated 181 potential risk factors, including demographics, socioeconomic status, lifestyle and health behaviors, health history, psycho-social factors and more.

SLEEPY DURING THE DAY? IT COULD BE AN EARLY WARNING SIGN OF DEMENTIA, STUDY SUGGESTS

Below are some of the strongest predictors at age 60 that indicate a higher chance of developing cognitive impairment and dementia, according to the report.

1. Poor physical health

2. History of stroke

3. Genetics

4. Being born in the Southern United States

5. Not having private health insurance at age 60

6. Never working or only working for a few years

7. History of diabetes

8. Having a body mass index of 35 or more

9. Never drinking alcohol or drinking excessively

10. Never exercising

11. Scoring low on physical tests

12. Being less conscientious

13. Low engagement in hobbies

14. Low cognitive function and engagement

Parental health, family size, marital history and demographics were the weakest predictors, according to the research.

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In a conversation with Fox News Digital, study co-author Peter Hudomiet, a RAND economist in California, shared details on the study, which worked with a large dataset and followed individuals “for decades.”

Parental health, family size, marital history and demographics were the weakest predictors, according to the research. (iStock)

“Overall, we found that risk factors had a similar effect in the short and long term, which reassured us that the findings from prior literature may hold in the long term,” he said.

“Nevertheless, we also had quite a few surprising findings.”

Digging into dementia drivers

The researcher was surprised to find that those who never exercised had a “substantially higher chance” of developing dementia than those who lightly exercised at least a few times per month.

“Exercising even more often (weekly or daily) had some additional benefits, but not that much,” he noted. “In other words, the main risk factor for dementia was never exercising.”

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“In fact, these behavioral factors were more important predictors of dementia than having the right genes,” Hudomiet added.

While having a body mass index (BMI) over 30 at age 60 was a weak predictor of dementia, a BMI over 35 was a “powerful predictor.”

The risk of dementia is “about half as much among those who regularly exercise compared to those who never do,” said the researcher (not pictured). (iStock)

Never participating in cognitive activities had a much higher risk of developing dementia compared to sometimes participating, as well as only having zero to 11 years of education compared to having high school or advanced degrees, said Hudomiet.

Another unexpected finding was the substantially higher dementia risk faced by Americans born in the Southeastern U.S. compared to the rest of the country.

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“This differential remained strong even when our statistical models accounted for differences in income, health, and other differences between regions,” the researcher noted.

“It is possible that the quality of education (which we could not measure in our data) was lower in the Southeastern part of the U.S., especially in the older cohorts we analyzed.”

“Less than 1% of healthcare dollars go towards educating the public on positive healthcare strategies,” according to gerontologist Dr. Marcie Smith.  (iStock)

People not covered by a private health insurance plan at age 60 had an 11% higher chance of developing dementia than those who had coverage, Hudomiet added.

“[That’s] partly because private health insurance helps individuals remain healthy longer,” he suggested.

“The choices you make now will determine how you will live later.”

The study results suggest that “maintaining good physical and mental health is beneficial not just to staying in shape, but also to staying sharp and delaying cognitive decline,” Hudomiet told Fox News Digital.

DEMENTIA HAS 2 SHOCKING NEW RISK FACTORS, STUDY FINDS, WITH TOTAL OF 14 NOW ON LIST

Gerontologist Dr. Macie P. Smith in South Carolina, who was not involved in the study, also reacted to the findings in a separate conversation with Fox News Digital, stating that the researchers are “spot on.”

“Having this researched information presented … brings about a heightened sense of responsibility to everyone who claims to be in the fight to end Alzheimer’s disease and related dementias (ADRD),” she wrote in an email response.

Genetics is less of a risk factor than certain habits and behaviors like exercise, the researcher noted. (iStock)

Smith said it is “pretty shocking” that never drinking alcohol increases dementia risk.

“This stands out to me because drinking alcohol excessively increases one’s risk significantly of brain deterioration and can lead to alcohol-induced dementia,” she said. 

The expert suggested that self-reported data could have led to this finding, or red wine could have been factored in, as it’s been found to “contain brain-enhancing nutrients, such as resveratrol.”

Ways to reduce the risk

While cognitive decline is sometimes impossible to prevent, Hudomiet mentioned that some risk factors can be reduced through lifestyle changes.

These include exercising regularly, maintaining a healthy body weight, getting proper nutrition and engaging in challenging cognitive activities.

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“Health care providers and the government should consider promoting healthy behaviors in the adult population and strengthening individuals’ access to quality health care, which may decrease the prevalence of dementia and the burden of the disease in the future,” Hudomiet recommended.

“Understanding that what’s good for the heart is good for the brain and adopting healthy lifestyle practices puts people in control of their brain fate,” one expert said. (iStock)

Smith added that reducing dementia risk “doesn’t begin or end with medication.”

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For those who are middle-aged, paying attention to these early predictors is a “matter of life and death,” she stated.

“It is incumbent on everyone with a brain to take heed of the warning signs that your body gives you,” she said. “Your body always reminds you about what your brain sometimes ignores.”

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“You have the power to take control over what your life looks like down the road,” she went on. 

“The choices you make now will determine how you will live later.”

Heart failure has historically been irreversible, but the outcome of a new study suggests that could someday change.

At the University of Utah, scientists used a new gene therapy that was shown to reverse the effects of heart failure in a large animal study.

In the study, pigs with heart failure were found to have low levels of cardiac bridging integrator 1 (cBIN1), a critical heart protein.

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The scientists injected a harmless virus into the pigs’ bloodstreams to carry the cBIN1 gene into their heart cells, according to a university press release.

The pigs survived for the six-month duration of the study, while they would have been expected to die from heart failure without the gene therapy.

In what the researchers called an “unprecedented recovery of cardiac function,” the IV injection appeared to improve heart function by increasing the amount of blood it can pump, which “dramatically improves survival.”

The pigs’ hearts also appeared to be “less dilated and less thinned out” after the therapy, “closer in appearance to that of non-failing hearts.”

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While previous attempts to treat heart failure improved function by just 5% to 10%, the gene therapy used in the new study resulted in 30% improvement, according to the researchers.

The study, which was funded by the National Institutes of Health, was published on Tuesday in the journal npj Regenerative Medicine.

Microscope images of failing heart cells (top) and heart cells that received gene therapy (bottom). Cell boundaries, labeled in magenta, are more organized after gene therapy, and the level of cBIN1 protein (green) is higher. (Hong Lab)

“Even though the animals are still facing stress on the heart to induce heart failure, in animals that got the treatment, we saw recovery of heart function and that the heart also stabilizes or shrinks,” said TingTing Hong, MD, PhD, associate professor of pharmacology and toxicology at the University of Utah, in the release.

“We call this reverse remodeling. It’s going back to what the normal heart should look like.”

“A possible new therapy to cure heart failure is on the way,” Hong told Fox News Digital in a statement.

“A possible new therapy to cure heart failure is on the way.”

The researchers were surprised to find that the gene therapy worked so well in large animals at such a low dose, Hong added.

Co-senior author Robin Shaw, MD, PhD, director of the Nora Eccles Harrison Cardiovascular Research and Training Institute at the University of Utah, said the “unprecedented” study ushers in a “new paradigm” for heart failure treatments.

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“Given our treatment efficacy, the complex multi-organ syndrome of heart failure can be reduced to a treatable disease of failing heart muscle,” he told Fox News Digital via email.

“The toxicity of gene therapy increases with dose, so our low dose suggests that our gene therapy approach will be safe for patients.”

While gene therapy has historically been used for rare diseases, the study results suggest that it could also be an effective approach for “acquired disease,” a researcher said. (iStock)

While gene therapy has historically been used for rare diseases, the study results suggest that it could also be an effective approach for “acquired disease,” according to Shaw.

The study did have some limitations, the researchers acknowledged.

“Dose escalation and toxicology studies are still needed for the therapy to move to the next step [toward FDA approval],” Hong noted. 

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It is also uncertain whether the gene therapy will work for people who have obtained a natural immunity to the virus that carries the therapy, the researchers said.

The toxicology study is currently underway, and the team plans to start human clinical trials in the fall of 2025, Hong said.

Cardiologists weigh in

Dr. Jasdeep Dalawari, interventional cardiologist and regional chief medical officer at VitalSolution, an Ingenovis Health Company based in Ohio, was not involved in the research but shared his reaction to the findings.

“Gene therapy, precision medicine and personalized health care is the future.”

“Research in the animal phase is always interesting, but the application to human test subjects is necessary in terms of understanding if this approach would have the same effect in humans,” he told Fox News Digital.

While previous attempts to treat heart failure improved function by just 5% to 10%, the gene therapy used in the new study resulted in 30% improvement, according to the researchers. (iStock)

“That said, there are many genetic modifications happening in different diseases, like cystic fibrosis and muscular dystrophy, that are looking at a similar intervention – injecting healthy genes in the hopes of finding cures,” he went on.

“Gene therapy, precision medicine and personalized health care is the future, and I look forward to learning more about this.”

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Dr. Johanna Contreras, advanced heart failure and transplant cardiologist at the Mount Sinai Fuster Heart Hospital in New York City, noted that conventional pharmacological interventions can help to alleviate cardiac stress and “systemic congestion,” but “for the most part, they do not address the pathogenic remodeling of failing heart muscle.”

About 6.7 million adults in the U.S. have heart failure, statistics show. (iStock)

“Gene therapy has emerged as a new modality that could interfere or modify the expression of several proteins, thus it could alter the pathologic remodeling of the heart muscle that exists in heart failure,” Contreras, who also was not involved in the study, told Fox News Digital. 

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Contreras reiterated that human trials are needed to determine whether this therapy will be effective outside animal models and to identify any “downstream effects.”

“I will look forward to learning more and eventually learning if this could one day be applied to humans with heart failure.”