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A Blood Test Predicts Pre-eclampsia in Pregnant Women

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The Food and Drug Administration has approved a blood test that can identify pregnant women who are at imminent risk of developing a severe form of high blood pressure called pre-eclampsia, a leading cause of disability and death among childbearing women.

The condition disproportionately affects Black women in the United States and may have contributed to the recent death of Tori Bowie, a track star who won gold at the 2016 Olympics. Two Black teammates of Ms. Bowie — Allyson Felix and Tianna Bartoletta — also developed pre-eclampsia during their pregnancies.

The new test may offer an early warning, identifying which of the many pregnant women who have suggestive symptoms will go on to develop the life-threatening disease within the next two weeks.

“It’s groundbreaking. It’s revolutionary,” Dr. Doug Woelkers, a professor of maternal fetal medicine at the University of California, San Diego, said of the test. “It’s the first step forward in pre-eclampsia diagnostics since 1900, when the condition was first defined.”

To what extent the test will improve outcomes and save lives is not clear, however, as there is no effective treatment for pre-eclampsia, which usually eases after birth.

“We don’t have a therapy that reverses or cures pre-eclampsia other than delivery of the baby, which is more like a last resort,” Dr. Woelkers said.

The new blood test, made by Thermo Fisher Scientific, has been available in Europe for several years. It is intended for pregnant women who are hospitalized for a blood pressure disorder in the 23rd to 35th weeks of gestation.

The test can tell, with up to 96 percent accuracy, who will not develop pre-eclampsia within the next two weeks and so can safely be discharged from the hospital. Two-thirds of the women who get a positive result, on the other hand, will progress to severe pre-eclampsia in that time, and their babies may need to be delivered early.

Distinguishing between the two groups of women is a challenge that has long vexed physicians.

“The warning signs of pre-eclampsia are not very specific,” said Dr. Sarosh Rana, a professor of obstetrics and gynecology at the University of Chicago who has studied the test. “A lot of women will have edema and headaches.” (Edema means swelling.)

“But we don’t really know who among those patients is at higher risk for the really adverse outcomes,” she said.

Pre-eclampsia affects about one in 25 pregnancies, and the incidence has been on the rise in recent years in the United States. The problem usually starts about halfway through a pregnancy, though it can also occur after childbirth. It can lead to a condition called eclampsia, which can lead to seizures and death.

Black women in the United States have pre-eclampsia rates much higher than those of white women, and they are three times as likely as white women to suffer kidney damage or death from pre-eclampsia. Black women are also more likely to lose their babies.

The blood test measures the ratio of two proteins that are produced by the placenta. A study published in NEJM Evidence in November tracked 1,014 pregnant women hospitalized with a hypertensive disorder of pregnancy at 18 medical centers in the United States from 2019 through 2021. Just under one-third were Black, and 16 percent were Hispanic.

The researchers found that the two proteins were greatly unbalanced in the blood of women who developed severe pre-eclampsia. Those with the widest ratios had a 65 percent chance of progressing to severe pre-eclampsia and of delivering their baby within two weeks, either spontaneously or through induction.

“If your levels are among the highest, you deliver in a few days,” said Dr. Ravi Thadhani, an author of the study.

Women who have symptoms suggesting pre-eclampsia but who test negative can be reassured and sent home, but they may need to have the test repeated every two weeks, Dr. Rana said.

Pre-eclampsia develops precipitously, and without the blood test, the warning signs can be vague.

“A woman can go from feeling fine and being completely healthy and having normal kidney and liver function, and within 24 to 48 hours those organs can fail and she develops brain swelling and seizures,” Dr. Thadhani said. “That is the scary part of the disease.”

U.S. Ambassador to Russia Allowed to Meet With Detained WSJ Reporter Evan Gershkovich

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The U.S. ambassador to Russia, Lynne M. Tracy, met with the detained Wall Street Journal correspondent Evan Gershkovich at Lefortovo Prison in Moscow on Monday, according to the State Department.

It was the first time since April 17 that an American diplomatic official had been able to meet with Mr. Gershkovich, who has been held for more than 13 weeks on what American officials have said are bogus allegations of espionage.

Ms. Tracy reported that Mr. Gershkovich was in “good health” and remained “strong, despite his circumstances.” Mr. Gershkovich, 31, has been held since late March at Lefortovo, a high-security jail known for difficult conditions for inmates, including extreme isolation.

The Russian government’s allegations against Mr. Gershkovich have been vehemently rejected by the United States government and The Journal. The State Department reiterated on Monday that Mr. Gershkovich had been “wrongfully detained” — meaning that the U.S. government considers him to be the equivalent of a political hostage.

American officials repeated their call for Russia to immediately release Mr. Gershkovich and Paul Whelan, 53, a former U.S. Marine that the U.S. government also considers wrongfully detained. He is serving a 16-year sentence after being convicted in 2020 of spying.

Based in Russia for almost six years, Mr. Gershkovich was first detained on March 29 during a reporting trip to the central Russian city of Yekaterinburg. Thursday would be his 100th day in detention.

If convicted on the espionage charges, for which Russian prosecutors have offered no evidence, Mr. Gershkovich could face 20 years in a penal colony.

In June, a Moscow court denied an appeal by the journalist’s lawyers to end his pretrial detention, which had been extended to Aug. 30. Mrs. Tracy attended that court session, along with Mr. Gershkovich’s parents, Ella Milman and Mikhail Gershkovich.

‘Wondered how much longer’ he’d have with his kids

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Rep. Joaquin Castro (D-Texas) discussed his rare cancer diagnosis in a Monday Twitter thread, saying he originally found out he had the disease after a car wreck in Spain. In the series of posts, Castro, a member of Congress since 2013, said he initially wondered how much time he’d have left with his Kids.

“My younger daughter turned two months old on the day of my accident. I wondered how much longer my kids would have their dad around,” Castro wrote.

Castro had surgery in February to remove tumors from his gastrointestinal tract.

“I could hardly pronounce “neuroendocrine” tumor, a rare form of cancer, when I got to MD Anderson in mid-July 2022,” Castro tweeted. “But I knew that any tumor spreading across your body isn’t good. I hadn’t told many people about my diagnosis even as so many things raced through my mind.”

Castro wrote that he found out he was diagnosed with a neuroendocrine tumor after sustaining injuries when the driver of his car hit a boar that ran into the road while he was at a summit in Spain. Castro now says that incident saved his life.

A neuroendocrine tumor forms from cells that release hormones into the blood in response to a signal from the nervous system, according to the National Cancer Institute. Neuroendocrine tumors may make higher-than-normal amounts of hormones, which can cause many different symptoms.

“Between two languages I heard — ‘My radiologist called me. He said he believes he sees two neuroendocrine tumors that have spread from your small intestine to your liver. I hate to be the bearer of bad news.’ I asked some questions and then she left,” Castro wrote. “I never got a bill.”

Castro, 48, is one of the multiple lawmakers to announce a cancer diagnosis in recent months.

Rep. Jamie Raskin (D-Md.) shared last December that he had been diagnosed with a diffuse large B cell lymphoma, calling it “a serious but curable form of cancer.”

Raskin, a former member of the now-defunct House select committee investigating the Jan. 6, 2021, attack at the Capitol, shared in April that his cancer is in remission.

Rep. Dan Kildee (D-Mich.) announced earlier this year he was diagnosed with squamous cell carcinoma, a serious but curable form of cancer. Kildee announced last month that his cancer is “gone” after undergoing surgery for it.

For the latest news, weather, sports, and streaming video, head to The Hill.

Mets and Yankees Get Only Three All-Star Selections

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The Mets and the Yankees have the two largest payrolls in Major League Baseball, with more than $600 million in combined player salaries, according to Spotrac. Luxury tax bills, which will be finalized later this year, will push the combined number well over $700 million.

For all of that money, the teams had a total of three players selected to the rosters of this year’s All-Star Game, which were announced on Sunday night. Pitcher Gerrit Cole and the injured outfielder Aaron Judge will represent the Yankees at the game in Seattle on July 11. First baseman Pete Alonso will represent the Mets.

Last year, with both teams thriving, they combined for 10 All-Star selections.

The Yankees, who are 46-38 and currently in position for the American League’s third wild-card spot in the playoffs, have had at least one player appear in 90 of the 92 All-Star Games, which have been held since 1933. But because of injuries and rest, it remains an open question if they will have anyone participate in this year’s game.

Judge, who was elected as a starter for the A.L., has 19 home runs but has been limited to 49 games because of a toe injury that will keep him out indefinitely. Cole, who is having a stellar season with a 2.79 E.R.A., pitched Sunday, and would normally pitch next on Friday, leaving him a day short of his normal rest. But with Carlos Rodón expected to come off the injured list to start Friday’s game, Cole could move to Saturday, giving him even less time to recover before the All-Star Game.

Despite the rest issue, Cole talked as if he intended to play in the game.

“One of these days, I would really like to start it,” Cole told reporters over the weekend. “I’ve got to check that one off. I’m not sure how that shakes out over the next week. I know there’s a lot of deserving guys out there.”

His competition to start would include the former Yankee Nathan Eovaldi, who is thriving for the Texas Rangers, and Shohei Ohtani, the two-way superstar of the Los Angeles Angels who started for the A.L. last year.

For the Mets, who have been a colossal disappointment at 38-46 despite their record payroll, Alonso is a reasonable choice as their lone representative. His .221 batting average is the worst of his career, and he trails outfielder Brandon Nimmo and shortstop Francisco Lindor for the team’s lead in wins above replacement, but his 25 home runs are second in the National League to Matt Olson of the Atlanta Braves.

Additionally, Alonso announced that he would participate next Monday in the Home Run Derby, an event he has dominated in the past. He won the derby in 2019 and 2021 and was a quarterfinalist last year. While the formats change from year to year, making comparisons difficult, his 174 home runs in three contests are the most combined homers in the event’s history.

Manager Buck Showalter told reporters over the weekend that he thought the All-Star selection and participation in the Home Run Derby could help bring Alonso out of his recent slump.

“I hate to see good people beat themselves up,” Showalter said. “But I think it is good timing for him to be reminded how good of a player he is. I think he is one of the league leaders in unluckiness, so to speak. Pete is as real as it gets.”

The Mets came into the season with World Series aspirations only to have the team’s owner, Steven A. Cohen, acknowledge last week that they could be sellers at the trading deadline. Putting some salt in that wound: Atlanta, which leads the Mets by 18.5 games in the N.L. East despite spending more than $100 million less in payroll than their division rival, will send an M.L.B.-high eight players to the All-Star Game.

5 Electric Vehicle-Friendly Road Trips With Ample Charging Stations

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“It’s a different mind-set, but it doesn’t bother me that I might have to stop for 20 minutes, or even longer,” said Mr. Cowing, 41, a father of two and the chief executive and founder of Protectli, a computer hardware manufacturer. “Especially with kids. By the time we all get out of the car and into the bathroom, grab some snacks, it’s not such a big deal.”

Here are five scenic drives around the United States that are well suited to E.V. travel:

California is lousy with scenic drives, from its extensive, 840-mile coastline to routes through the magnificent Sierra Nevada. But it’s hard to beat the majesty of the coast north of San Francisco, where Highway 1 twists and turns along vertiginous cliffs and jaw-dropping panoramas of the wild Pacific. Head north from San Francisco to Point Reyes National Seashore before following the coast through Bodega Bay and Jenner, where a meal or an overnight at the Timber Cove Resort or the Sea Ranch Lodge will recharge you for the 60-mile leg to the picturesque town of Mendocino. Loop back and head east through the redwood forests of Philo and Boonville and south to San Francisco via Highway 101, right through Sonoma wine country. You’ll find charging stops in Healdsburg, Sebastopol, Sonoma and Petaluma, and wineries like Ridge and Martin Ray are equipped with Convenient Charging Stations as well.

The Pacific Northwest is a gold mine of stunning scenery, boasting everything from rugged coastline and towering mountains to wildlife-rich forests. The White Pass Scenic Byway cuts through the heart of Washington from between the towns of Chehalis and Castle Rock to Naches via U.S. Route 12. The 120-mile route is a fine way to explore much of the wild and remote parts of the state, including a stretch that passes through Okanogan-Wenatchee and Gifford Pinchot National Forests and offers views of Mount Rainier. The road, winding past rivers and waterfalls, is known as a place for excellent wildlife spotting; it’s also a great starting point for hikes, fishing trips and more (find suggested itineraries online or via the byway’s trip planner app). The route is also the focus of a new electric vehicle-centric initiative, with eight new E.V. charging stations are currently being built, all of which will have at least one Level 3 fast charger. (A ribbon cutting for the newly electrified route is planned for July 11.)

Colorado has been a leader in the United States when it comes to electrifying its scenic routes, and has committed to installing charging stations on its 26 scenic and historic byways by 2030. While there’s no way to go wrong when planning a Colorado road trip — circuits in the Rockies, through the desert and around historic mining towns are all options — we love the West Elk Loop for its combination of natural beauty, wildlife viewing and destination-worthy towns. Circling the West Elk Mountains, highlights include the charming towns of Carbondale and Crested Butte, fruit orchards and wineries in the North Fork Valley and the absolutely jaw-dropping beauty of the Black Canyon of the Gunnison National Park. The route takes you past opportunities for boating, mountain biking and hot springs dips, plus live music and art festivals in the summertime.

A road trip between Santa Fe and Taos — two standout New Mexico destinations — is a decided win. The route has beautiful scenery, a dose of history and is easily doable in an E.V. Start by accessing the state’s helpful E.V. planning tool and then hit the 56-mile High Road to Taos, which passes through villages with epic views of the Sangre de Cristo Mountains. Worthy stops include El Santuario de Chimayo, a church built in 1813 that’s still a destination for pilgrims. From Taos, the Enchanted Circle Scenic Byway winds through striking mountain scenery (some of which was featured in “Butch Cassidy and the Sundance Kid”) and mountain towns like Red River and Questa — these towns are excellent bases for hiking, fishing and other outdoor adventures. A detour to Taos Ski Valley is well worth taking, both for a charge and for mountain biking. Reporters Newswire.

One Black Family, One Affirmative Action Ruling, and Lots of Thoughts

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For the Whiteheads, an African American family living in the city of Baltimore, race is discussed at the dinner table. In the car on the way to work and school and games. In the backyard while the sons practice sports.

So when the Supreme Court struck down race-conscious admissions at colleges and universities, effectively ending the practice known as affirmative action, the family began talking about it earnestly, echoing the range of emotions felt by people across the country who are invested in the ruling.

Though the result was anticipated, Karsonya Wise Whitehead, 54, a college professor, said she was so devastated that she had to sit down to process “the type of history being made at that moment.”

Her husband, Johnnie Whitehead, 59, the principal of a Christian school, said he took no joy in the ruling but was ambivalent about affirmative action. He is hopeful that it is no longer needed, but fears it is.

The eldest son, Kofi, 22, texted his brother Amir to share the news, and thought of the chilling effect it might have on the next generation of Black students. Amir, 20, felt that ending affirmative action was not wrong because admissions should be based upon merits only.

For the Whiteheads, the Supreme Court decision — seismic in its power to reorder the admissions process at elite colleges and universities — was another chapter in a broader discussion they had been having since their children were young.

Their conversation reflects, in some ways, the complex and shifting views among African Americans grappling with the question embedded in the nation’s every contemporary racial conflict, from reparations to the American justice system: How to deal with the legacy of slavery?

“This is part of our ongoing conversation about the tensions around racism and around race,” said Dr. Whitehead, who teaches African American studies and communications at Loyola University Maryland and is the executive director of the Karson Institute for Race, Peace and Social Justice at the college. “We’ve seen different iterations of: ‘What does it mean to be Black in America? Where do we fit into America? Whose America is this? And if we want to have equity, what does this equity look like?’”

The family’s early talks centered on making sure their sons were confident in who they were as young Black men. That gave way to other topics.

Kofi favors reparations but doesn’t know what the right amount of money should be for Black families whose ancestors were enslaved. Amir favors reparations in some form, too, saying, “We built this country, we deserve some part of it.” Dr. Whitehead is not only in support, but she believes it is the only way forward to address the historical debt. Mr. Whitehead said Black Americans deserved reparations, particularly since the country had paid others that it harmed, but did not see it as a way to solve racism.

When it comes to affirmative action, African Americans are broadly supportive of the policy.

According to a Pew Research Center report released last month, only 33 percent of American adults approve of race-conscious admissions at selective colleges. Forty-seven percent of African American adults say they approve.

The research also revealed that 28 percent of Black adults said others had assumed that they benefited unfairly from efforts to increase racial and ethnic diversity.

A separate NBC poll in April found about half of Americans agreed that an affirmative action program was still necessary “to counteract the effects of discrimination against minorities, and are a good idea as long as there are no rigid quotas.” Among African Americans, the number in support of that statement increased to about 77 percent.

The starkly different attitudes toward the merits of affirmative action were laid bare most profoundly in the words of the only two Black justices. Their written exchange mirrored how the landmark decision was discussed, debated and deconstructed among friends and families — including the Whiteheads — at dinner tables, in group chats and on social media.

Justices Clarence Thomas, who attended Yale, and Ketanji Brown Jackson, who attended Harvard, challenged each other’s views, agreeing only on the existence of racial disparities but sharply disagreeing on how to address them.

“As she sees things, we are all inexorably trapped in a fundamentally racist society, with the original sin of slavery and the historical subjugation of Black Americans still determining our lives today,” wrote Justice Thomas, the nation’s second Black justice and a longtime critic of affirmative action.

Justice Jackson, in her dissent, said Justice Thomas “is somehow persuaded that these realities have no bearing on a fair assessment of ‘individual achievement,’” she wrote. In her opinion, the court’s conservative majority displayed a “let-them-eat-cake obliviousness” on the issue of race.

In some ways, the Whiteheads’ views of affirmative action aligned with both of the justices’ argument outlined on the pages of the ruling.

For Ms. Whitehead, a radio show host, author and the daughter of civil rights activists, the dismantling of affirmative action — rooted in the civil rights movement as part of federal policy to counteract discrimination — was a “gut punch.” She said she personally benefited from affirmative action as the first Black student in the Kroc Institute for International Peace Studies program at the University of Notre Dame. She worries that the decision portends what is to come, shaping other aspects of life, including corporate hiring.

Mr. Whitehead said he understood the practice as a way to counter discrimination and mistreatment of African Americans. And, he said, if affirmative action is going to be abolished, legacy preferences should go, too.

“I’d like to believe that we are a nation that doesn’t have to have affirmative action, but I fear we still need it,” said Mr. Whitehead, who is also a teacher at Baltimore School of the Bible.

Kofi, the eldest son, who graduated from Rhodes College in May with an English degree, has a sensibility closer to his mother’s. He first began following the issue in high school after learning about a white student in Texas who sued the University of Texas at Austin for its use of race in admission decisions.

He sees last week’s ruling as both out of touch with the pervasiveness of modern racism and a blow to future generations of Black students looking to attend elite schools. And he chafes at the argument that college academic standards are lowered to create diverse campuses.

“Affirmative action is about opening the door to diverse backgrounds because that is what education and higher learning is about,” Kofi said. “It’s not about having 5,000 of the same kids in two-parent households and white picket fences who all come in and do the same thing. No. College and higher education is about bringing in different people so you can learn from each other.”

His younger brother Amir, who is a member of Lafayette College’s fencing team, sees it differently. A college sophomore who is studying economics, he began developing his political and socially conservative views as a middle school student during the presidential race between Hillary Clinton and Donald J. Trump.

While he and his mother’s views are the farthest apart, she said he was raised “to be an independent thinker.”

He agrees with the other members of his family that race, and the nation’s history of enslavement of Black people, undeniably affects the present day. But, he said he believed that affirmative action undermined the concept of earning admission based on qualifications rather than race.

“Affirmative action being taken away is not so much a bad thing, because I don’t think that anyone who is not qualified for something should get that purely based off their skin color,” said Amir, who noted that he included his race on his college application but did not include the subject in his personal essay.

“I am not saying the bar has been lowered,” he said. “I just feel as though sometimes, cases come down to race. I think that goes back to us, as a country, where everything is focused on race.”

Court ‘Has Not Been Receiving Adequate Oversight’ (Video)

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After a week of decisions that struck down affirmative action at universities, ruled against President Biden’s college debt cancellation and loosened protections for LGBTQ persons, the Supreme Court has drawn the ire of many – including Rep. Alexandria Ocasio-Cortez, who says the Court “has not been receiving adequate oversight.”

Appearing on CNN on Sunday, AOC called attention to the controversies concerning Supreme Court Justices Samuel Alito and Clarence Thomas and said a subpoena for Chief Justice Roberts isn’t out of the question.

“We have a senate judiciary committee that is beginning the process of investigating the entanglements and conflicts of interest. Just one to two weeks before the student loan ruling, the country learned that Justice Samuel Alito was accepting gifts from billionaires who were lobbying before the Supreme Court against student loan forgiveness,” she said. “I believe that if Chief Justice Roberts will not come before Congress for an investigation voluntarily, I believe that we should be considering subpoenas, we should be considering investigations.”

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The New York congresswoman continued, saying impeachment should also be on the table.

“We must pass much more binding and stringent ethics guidelines where we see members of the Supreme Court potentially breaking the law, as we saw in the refusal with Clarence Thomas to recuse himself from cases implicating his wife in January 6. There also must be impeachment on the table.”

Ocasio-Cortez also said the Court has put its own legitimacy into question.

“We have a broad level of tools to deal with misconduct, overreach and abuse of power and the Supreme Court has not been receiving the adequate oversight necessary in order to preserve their own legitimacy, and in the process they themselves have been destroying the legitimacy of court, which is profoundly dangerous for our democracy.”

The Supreme Court’s decisions this past week inflamed many, including Supreme Court Justice Ketanji Brown-Jackson who issued a scathing dissent in the case that effectively put an end to affirmative action at colleges.

“With let-them-eat-cake obliviousness, today, the majority pulls the ripcord and announces ‘colorblindness for all’ by legal fiat,” the dissent read in part. “But deeming race irrelevant in law does not make it so in life. And having so detached itself from this country’s actual past and present experiences, the Court has now been lured into interfering with the crucial work that UNC and other institutions of higher learning are doing to solve America’s real-world problems.”

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Andy Murray Returns to Wimbledon a Man in Full and on a Mission

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In late May, with most of the world’s best tennis players focused on the red clay at the French Open, Sir Andy Murray was 300 miles away on the other side of the English Channel, dialed in on preparations for the grass at Wimbledon.

That had been the plan, anyway. But then his wife, Kim Sears, had to head up to Scotland for a few days to handle some business at the hotel she and Murray own. That left him solo for the morning rituals beginning at 5:30 a.m. with their four children, all younger than 8: cooking breakfast, getting everyone dressed and dropping them off at school.

Three hours later, with the last child delivered, he headed to Britain’s national tennis center in Roehampton, where he received treatment from his physiotherapist and trained for several hours on the grass court and in the gym. There was also an afternoon of interviews and shooting promotional videos. It’s all part of the next phase of Murray’s quixotic, late-career quest to finish his journey on his terms, metal hip and all.

Maybe that means somehow recapturing the magic of 10 years ago, when he became the first British man in 77 years to win the most important title in his sport. Maybe it’s simply cracking the top 30 or 20 once more, proving wrong all the doctors and doubters who called him foolish for entertaining a future in professional tennis after hip resurfacing surgery in 2019.

Or maybe it’s pushing off for however long he can be the full-time tennis elder, entrepreneur and someone who, years ago, did that glorious thing.

The default demeanor that accompanies Murray’s grueling physical play has always looked something like misery, peppered with a near-constant verbal self-flagellation that pulls spectators into his battle. But there is also joy in the training, the competing, the quest to improve and get the most out of himself while doing something that he loves, even when that means struggling against seemingly inferior opponents. Murray knows nothing else he does will ever match the feeling. So he goes on, results be damned.

“I’m jealous of your Jannik Sinners and these young guys that have got an amazing career to look forward to,” he said during a recent interview at the end of that harried day as he headed for the tennis center parking lot. “I would love to do it all over again.”

A decade on from the moment Britain had been waiting on since the Great Depression, Murray returns to the All England Club a version of himself that he could not have imagined in 2013, when he was just another 20-something bloke who walked his dogs in London on the south bank of the Thames.

The tennis obsessive is now a man in full: a husband of eight years; a father of four; an officer of the Order of the British Empire (hence the “sir”); an art collector; an entrepreneur with a portfolio that includes a hotel, a clothing line and other investments; and the wise man, sounding board and occasional practice partner for the next generation of British tennis stars, such as Jack Draper and Emma Raducanu.

Mirra Andreeva, the 16-year-old Russian phenom, would like some time with him, too. She called him “so beautiful” this spring.

Regrets, he has a few, especially in those years in his 20s when he trained like a fiend and viewed time with friends and family as an impediment to a tireless search for every ounce of success. Another speed workout. More lifting, or hot yoga, or hitting practice balls. Why did he make life so difficult for his coaches? Why did he eat all those sweet-and-sour candies? Why did he stay up until 3 a.m. playing video games so often?

The lazy view of Murray, who plays Ryan Peniston of Britain in the first round on Tuesday, is a player with just three Grand Slam singles titles, the same as Stan Wawrinka, who is a fine champion but no one’s idea of an all-time great. Novak Djokovic just won his 23rd. Rafael Nadal has 22; Roger Federer, 20. They are the so-called Big Three.

Djokovic said recently he doesn’t much like that term because it excludes Murray, a player he has been battling since his days on the junior tennis circuit. The longtime mates practiced together on Saturday at the All England Club.

There is a reason Federer included Murray as a central character in his send-off last year at the Laver Cup. Murray has beaten Djokovic, Nadal and Federer a combined 29 times, including two wins over Djokovic in Grand Slam finals. He made 11 Grand Slam singles finals during the most competitive era of elite men’s tennis. Only he, Nadal, Federer and Djokovic held a No. 1 ranking between 2004 and 2022. And he withstood unmatched pressure during his run to that first Wimbledon title.

“It’s an outrageous career,” said Jamie Murray, a top doubles player who teamed with Andy, his younger sibling, in 2015 to deliver Britain its first Davis Cup triumph since 1936.

Or it was an outrageous career, until that grueling physical style exacted its toll on Murray’s back and ankles and eventually led to the degenerative hip condition that stymied his run at the top in 2017. In January 2018, Murray had an initial unsuccessful hip surgery. For the rest of the season, everyone saw him suffering and limping through the pain.

At the 2019 Australian Open, Bob Bryan, a 23-time Grand Slam doubles champion, put his breakfast tray down at Murray’s table and told him about the hip resurfacing surgery he had undergone the previous summer. The operation allowed Bryan to return to high-level competition doubles in just five months. Elite singles was something else entirely.

“‘All I want to do is play,’” Bryan said Murray told him.

Later that month, Murray posted a startling photo on Instagram that showed him lying in a hospital bed.

“I now have a metal hip,” he wrote after the roughly two-hour resurfacing procedure that replaced the damaged bone and cartilage with a metal shell. “Feeling a bit battered and bruised just now but hopefully that will be the end of my hip pain.”

Murray’s pain had grown so severe that the primary goal of the operation was to give him the ability to play with his children.

For the next six months, he attacked physical therapy and rehabilitation the way he had attacked tennis. He was a full-time father. He played golf. He hung around with old friends.

Matt Gentry, Murray’s longtime agent and business partner, said the downtime gave Murray a window into life without tennis. It wasn’t terrible.

Murray has long admired American sports stars who take an entrepreneurial approach to their careers, and he and Gentry began to map out opportunities. Murray has since launched a clothing line. He has invested with Tiger Woods and Rory McIlroy in TMRW Sports, a company that is seeking to find new ways to marry sports media and technology, including a new golf competition. He is part of a group that is building thousands of padel courts at sports clubs throughout the United Kingdom.

In 2013, he purchased Cromlix House, a 15-room castle-like hotel near his childhood home in Dunblane, Scotland, for roughly $2 million. The property was especially meaningful: His grandparents held their 25th anniversary party there in 1982. He and Sears held their wedding reception there. His brother, Jamie, also got married at the property.

Murray and Sears recently completed the first phase of a multimillion-dollar renovation and expansion of the property that will eventually include cabins by the nearby loch. The hotel is home to several pieces of art from Murray’s private collection, including a series of Damien Hirst and David Shrigley prints.

For now, Murray said, he mostly listens to pitches and writes checks, but he plans to become more involved in his business ventures when he is done playing tennis. If he has his way, that day will not arrive for some time.

Murray’s mother, Judy, a former player who was his first tennis coach, said tennis allows her son to express so many parts of his identity, beginning with a burning need to compete, but also an analytical mind that loves studying the game and its history.

From the time he was a small boy, she said, if a game of cards or dominoes wasn’t going his way, those cards and dominoes would go flying across the room. He also had an older and bigger brother he desperately wanted to beat, and plenty of people who said that a boy from a small town in Scotland, where the weather was terrible and indoor courts were scarce, could never win Wimbledon. Now those same people say his time has passed.

“If he still loves it, then why shouldn’t he keep playing?” Judy Murray said in an interview on Friday.

Murray said he has a rough idea of when and how he would like his tennis career to end, but he knows it might not be his choice. Federer desperately wanted to play more, but his knee wouldn’t allow it. Murray has seen the videos of Nadal limping off the court in Australia in January with a torn muscle and hip injury from which he may never fully recover.

Murray knows that his next desperate sprint for a drop shot, or one of his signature points earned while running the baseline back and forth, back and forth, back and forth, could be his last. Then again, he could still be doing this three years from now, which carries its own unique complications.

He recently ran out of his stash of the bulky, extra-support tennis shoes that Under Armour manufactured for him until their last partnership deal expired. So Murray had to call his friend Kevin Plank, the Under Armour founder, and ask if he could make him more shoes. Plank did.

In early June, when Djokovic and Carlos Alcaraz and nearly everyone else of consequence was playing in Paris, Murray was playing a Challenger tournament at a racket club in Surbiton, southwest of London, in the tennis minor leagues.

The field was made up of pro-tour deep cuts and some early round French Open casualties. A crowd of hundreds packed the stands, which were set on shaky scaffolding.

Murray took only a few games against Chung Hyeon, a journeyman from South Korea, to show why he is certain he can beat anyone in the world on grass at a time when so few pros have mastered the surface: the slice backhands that go successively lower until they barely bounce above an opponent’s shoelaces; the dying volleys in the front of the court, and the stinging ones to the baseline; the slice serve that slides so far off the court; the softballs that look like meatballs but are really knuckleballs, wobbling in the air and twisting when they hit the grass.

Two weeks and two Challenger trophies later, Murray had claimed 10 straight matches, the first five won while commuting from his home outside London, where he had decamped to a spare bedroom for the month to get some rest.

Then came his final Wimbledon tuneup, at Queen’s Club in London, where he lost his first match to Alex de Minaur of Australia, a top 20 player who took advantage of Murray’s heavy legs and lackluster serve that day. Murray tried not to read too much into the result.

All journeys have peaks and valleys. As the teachers in Murray’s hot yoga classes would say, the only way out is through — even on those days when the end feels closer than Murray hopes it might.

France Arrests Hundreds More in Fifth Night of Unrest

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The violent protests that have shaken France Unrest in response to the killing of a 17-year-old by a police officer continued for a fifth night, as the authorities arrested hundreds of people nationwide overnight Saturday, and demonstrators clashed with police officers in riot gear.

A government minister described the evening as calmer than recent ones, but local news media reported rioting, looting and clashes in Marseille, the second-largest city in France. While the number of officers deployed across the country had not increased, more were sent to quell protesters in Lyon, Grenoble and Marseille, according to the interior minister, Gérald Darmanin.

Tensions remained high after the funeral Saturday for the 17-year-old, of Algerian and Moroccan descent, who was fatally shot on Tuesday during a traffic stop in Nanterre, a Paris suburb. Many protesters saw themselves in the victim, connecting his fate with their own experiences of neglect and racial discrimination in France’s poorer urban suburbs.

In a statement on Twitter early Sunday, Mr. Darmanin, the interior minister, said 427 people had been arrested overnight on Saturday. On Friday night, more than 1,300 had been detained. He added that 45,000 police officers had been deployed across the country on Saturday evening, a number similar to the night before.

Maud Bodoukian contributed reporting.

Thousands of port workers in Canada’s British Columbia go on strike

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Breaking News: “Unfortunately, a tentative agreement could not be reached,” the British Columbia Maritime Employers Association (BCMEA) said in a statement, after meeting Thursday and Friday with the International Longshore and Warehouse Union Canada (ILWU Canada) in talks supported by the federal mediation agency.

ILWU workers were on strike at sites across British Columbia, the BCMEA said. Asked for comment, the union said it would issue a statement once there is a resolution to the dispute over the collective bargaining agreement, which covers about 7,500 employees at 30 terminals in the province.

The walkout could have serious consequences for Canada’s economy and small businesses, the Canadian Federation of Independent Business (CFIB) said in a statement. The group urged the government to ensure port operations are maintained.